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Premier League Weekend Preview: Manchester Derby, Isak’s Liverpool Debut, and Postecoglou Returns

Posted : 12 September 2025

Manchester City will be eager to halt a worrying run of results when they host neighbours Manchester United this weekend. Both sides have struggled early in the season, with City suffering back-to-back defeats to Tottenham and Brighton, raising questions over Pep Guardiola’s squad overhaul following last season’s third-place finish.

 

Injuries to key players, including Omar Marmoush, Rayan Cherki, and Mateo Kovacic, add to Guardiola’s challenges, while John Stones and several others remain doubtful after withdrawing from international duty.

 

Manchester United, meanwhile, finally recorded their first victory of the season after a last-minute penalty from Bruno Fernandes secured a win over Burnley.

 

Ruben Amorim’s side has endured a difficult start, including losses to Arsenal, a draw with Fulham, and an embarrassing League Cup exit at the hands of fourth-tier Grimsby.

 

The Manchester derby at the Etihad offers both teams a chance to restore confidence ahead of a congested fixture list.

 

In Liverpool, Alexander Isak is set to make his debut after a British-record £125 million transfer from Newcastle. The Sweden striker trained with his new teammates this week and is expected to start against Burnley.

 

Manager Arne Slot now faces the task of integrating Isak into a star-studded attack already featuring Mohamed Salah, Cody Gakpo, Florian Wirtz, and Hugo Ekitike, as Liverpool aim for their 21st English title.

 

Another highlight of the weekend is Ange Postecoglou’s return to Premier League management with Nottingham Forest. Hired three months after his sacking by Tottenham, the Australian coach faces immediate pressure against Arsenal.

 

Postecoglou inherits a team that qualified for European competition under Nuno Espirito Santo, but Forest’s demanding owner, Evangelos Marinakis, will be quick to demand results, making this an intriguing managerial storyline.

 

Other fixtures this weekend include Arsenal hosting Forest, Bournemouth against Brighton, Crystal Palace versus Sunderland, and a full slate on Sunday with Burnley taking on Liverpool and the Manchester derby concluding the weekend at 15:30 GMT.

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